排毒清火凉茶粉的急性毒性和致突变性实验研究

doi:10.3969/j.issn.1004-616x.2011.03.015

›› 2011, Vol. 23 ›› Issue (3): 219-221.doi: 10.3969/j.issn.1004-616x.2011.03.015

• 检测研究 • Previous Articles Next Articles

Study of toxicology on Paiduqinghuo herbal tea powder

WANG Lan1，ZHANG Yongdong1，GUO Hongyun1，ZHANG Xiaowen2，*，ZHAO Guangcai2，WANG Yu3

1. Center of Pharmacology and Toxicology, Gansu Province Academy of Medical Sciences, Lanzhou 730050, Gansu; 2. Department of Sports Nutrition,Guangzhou Institute of Sports Science, Guangzhou 510650，Guangdong; 3. College ofPublic Health, Lanzhou University, Lanzhou 730000, Gansu, China

Received:2010-09-13 Revised:2011-02-24 Online:2011-05-30 Published:2011-05-30
Contact: ZHANG Xiao-wen

Abstract

Abstract: To investigate the acute toxicity and mutagenicity test of Paiduqinghuo herbal tea powder and evaluate its safety. METHODS： The acute toxicity and mortality were observed，maximum tolerated dose was determined by using the maximum tolerated dose method. The mutagenicity was observed by Ames test，mouse sperm abnormality test， bone marrow cell micronucleus test, respectively. RESULTS： The maximum tolerated dose are 36 g/kg and 18 g/kg. Ames test results showed that using 5 doses of Paiduqinghuo herbal tea powder(100，500，1 000，2 500， 5 000 μg/plate，respectively)，the number of revertant colonies of TA97，TA98， TA100，TA102 strains were not significantly different compared with negative control group. Mouse sperm abnormality test results showed that the rate in herbal tea powder groups(3，6，12 g/kg，respectively) were 1.75%-1.92%，which had no significant difference compared with the control group(1.95%) (P > 0.05). Mouse bone marrow micronucleus test results showed that the micronucleus rate in herbal tea powder groups(3，6，12 g/kg，respectively) were 0.4‰-1‰， which had no significant difference compared with control group (0.6 ‰-0.8 ‰) (P > 0.05). CONCLUSION： Paiduqinghuo herbal tea powder is a non-toxic substance，under these experimental conditions，there was no mutagenic effect.

Key words: herbal tea, acute toxicity, mutagenicity, safety evaluation

WANG Lan1，ZHANG Yongdong1，GUO Hongyun1，ZHANG Xiaowen2，*，ZHAO Guangcai2，WANG Yu3. Study of toxicology on Paiduqinghuo herbal tea powder[J]. , 2011, 23(3): 219-221.

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Study of toxicology on Paiduqinghuo herbal tea powder

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